We are focusing on understanding the molecular mechanisms of RNA localization, translation, and stability in neurons and neurodegeneration and roles of RNA-binding proteins and non-coding RNAs in this process. Our lab is located in the center of Berlin at the Berlin Institute for Medical Systems Biology (BIMSB), a part of the Max Delbrück Center for Molecular Medicine (MDC).
We receive funding from:
Events and news
Our DFG proposal on translational control in neurodegeneration has been funded!
Enjoyed the retreat with the Ulitsky lab:
great science and an escape room!
Our manuscript explaining how SARS-CoV-2 uses the same protein NSP1 to inhibit the expression of host genes while enhancing that of viral RNA is out: https://rnajournal.cshlp.org/content/early/2022/03/01/rna.079086.121.full.pdf+html Congratulations to the first author and Master student in the lab Lucjia Bujanic! MDC press release: https://www.mdc-berlin.de/news/press/how-sars-cov-2-takes-over-cells-protein-factory
Happy to announce the continuation of the Berlin RNA club in 2022, co-organized with Samantha Mendonsa, Inga Lödige, and Tugce Aktas. We will meet every 2d Wednesday of the month at 5 pm. If you would like to join the club or present, let us know! https://www.chekulaevalab.org/rnaclubberlin
How do neuronal RNAs find their way to their final destination? Excited about our latest paper, a joint effort with Ulitsky lab, in which we describe neuronal zipcode identification protocol (N-zip).
Our preprint on how SARS-CoV-2 uses the same protein NSP1 to inhibit the expression of host genes while enhancing that of viral RNA is available at bioRxiv: https://www.biorxiv.org/content/10.1101/2021.09.13.460054v1
Our manuscript on the mechanisms of translational regulation in Charcot–Marie–Tooth disease is out. Congratulations to Samantha and Nicolai! https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab730/6353809
Congratulations to Samantha on the DAAD fellowship!
Our DFG proposal on the analysis of neuronal zipcodes has been funded!
Our manuscript on conservation of a core neurite transcriptome across neuronal types and species is out. Congratulations to Nicolai on the first-author manuscript! https://www.ncbi.nlm.nih.gov/pubmed/32059075
Congratulations to Larissa on the PhD thesis defence!
Congratulations to Samantha and Vsevolod on the award of DAAD fellowships!
Congratulations to Sayaka on the award of the Honjjo International Scholarship!
Congratulations to David on the PhD thesis defence!
Enjoying new location: our institute has moved to Berlin center, neighboring Charite and Humboldt University
Check out our Methods manuscript on how to isolate subcellular neuronal compartments: https://doi.org/10.1016/j.ymeth.2019.02.002
Teaching ribosome profiling to a great group of Master students from the Free University,
together with Samantha and Nicolai
Our manuscript on the alternative 3' UTRs directing localization of functionally diverse protein isoforms in neuronal compartments is out. Congratulations to Camilla on the first-author manuscript! https://doi.org/10.1093/nar/gky1270
Our DFG proposal has been funded!
Check out our review on roles of circRNAs and lncRNAs in translation: https://doi.org/10.1101/cshperspect.a032680
Our joint proposal with Igor Ulitsky (WIS) on identifying sequences driving subcellular localization has been funded by the German-Israeli Foundation for Scientific Research and Development (GIF)
Congratulations to Nicolai on the award of the MDC PhD fellowship!
Congratulations to Samantha on the award of the DAAD PhD fellowship!
Just completed ribosome profiling course for the RNA-enthusiasts from the Free University Biochemistry Master program. Next course is in July!
After a year in the lab, Inga Loedige has obtained her own DFG funding and started an independent research project. Proud to support Inga on the path to her scientific independence – we need more great female scientists in leading positions!
Our JPND consortium "localMND: Common architecture of local proteome, transcriptome and translatome across Motor Neuron disorders" has been funded! Check news and views article by Russ Hodge on the MDC website: https://www.mdc-berlin.de/news/news/red-thread-motor-neuron-disorders.
18.10.2017-14.02.2018 (every Wednesday 9.30)
BIMSB lecture series on RNA biology and disease, co-organized by Marina Chekulaeva and Markus Landthaler
Excellent speakers - check the program!
Check out our new manuscript on the role of RNAs localisation in neurons: http://dx.doi.org/10.1038/s41467-017-00690-6
Congratulations to Marta on the successful defense of her PhD thesis!
Congratulations to Alessandra, David, Camilla and Vedran
on the acceptance of their shared first-author manuscript!
Check out our collaborative manuscript on translation of circular RNAs: http://dx.doi.org/10.1016/j.molcel.2017.02.021
Check out our review on the methods used to quantify and visualize of translation: http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30478-6
We recieved funding from the DFG Priority Programme “Deciphering the mRNP code: RNA-bound Determinants of Post-transcriptional Gene Regulation”
Congratulations to Marta on the acceptance of her first-author manuscript!
Congratulations to Camilla on the award of the PhD fellowship from the Peter und Traudl Engelhorn Stiftung!
22.04.2015-16.07.2015 (every Wednesday 9.30)
BIMSB lecture series on RNA biology
co-organized by Marina Chekulaeva (BIMSB) and Benedikt Beckmann (HU)