The Herzel lab (FU, Berlin) aims to elucidate quantitative aspects of gene regulation, timing and coordination between the steps in the central dogma of molecular biology. We investigate this in the opportunistic fungal pathogen C. albicans and E. coli using methods from molecular biology, biochemistry and quantitative biology. Ultimately, they want to understand how fundamental aspects of gene regulation are tied in with regulation at the organismal level and pathology to harness such knowledge for biomedicine. The Herzel lab is a part of the Department Biology, Chemistry, Pharmacy at the Institute of Chemistry and Biochemistry and engage in collaborations within the FU Berlin, nationally as well as internationally, e.g. in Canada and the USA.
PhD positions available in the group of Prof. Dr. Lydia Herzel (AG RNA Dynamics) to work on (1) RNA binding protein dynamics and the transcript isoform landscape during developmental transitions of the opportunistic fungal pathogen Candida albicans, and (2) to work on system-wide RNA binding protein dynamics and the transcript isoform landscape during developmental transitions of Candida albicans. Most aspects of fundamental RNA biology remain to be understood in this biological model system that has strong biomedical potential, and thus many possible future directions can be envisioned. If you are interested, please apply with your CV, a short description of your Masters thesis project (or other equivalent research internships) and the contact information of two referees. This position aims for scientific qualification and includes participation in research and teaching.
A completed Masters (or equivalent) degree in Biology, Biochemistry, Biotechnology, Molecular Medicine or related fields.
To carry out the experiments in the yeast C. albicans prior experience in
• molecular biology,
• yeast biology,
• cellular protein and RNA biochemistry and
• biochemical cell fractionations
will be greatly valued.
The candidate should show
• a strong interest in RNA binding proteins and/or trancriptome dynamics,
• a high level of motivation to spearhead and develop this project,
• appetite to combine wet and dry lab experiments,
• good oral and written communication in English and
• the ability to work in a team.
Applications should be sent by e-mail, together with significant documents, indicating the reference code (RNA-Dynamiken-Yeast; RNA-Dynamiken-Comp), in PDF format (preferably as one document) to Lydia Herzel: [email protected]