Postdoc in RNA metabolism in ALS
ALS is a neurodegenerative disease affecting motor neurons, i.e. neurons that control skeletal muscle contraction to produce motion. Despite heterogeneous etiology, ALS is characterized by abnormalities in RNA metabolism. As a part of an international JPND research consortium, the successful candidate will work with the collection of ALS patient-derived hiPSCs and hiPSC-derived motor neurons to investigate how changes in RNA metabolism contribute to the mechanism of neurodegeneration. The project will reply on a combination of omics (transcriptomics, Ribo-seq, CLIP-seq), computational, CRISPR/Cas-mediated gene editing and imaging approaches. International collaboration partners will contribute different expertise to the project, including computational analysis, in vivo ALS models and clinical research.
Ideal candidate should have experience in cell culture and molecular biology techniques, interest in RNA biology and neurodegeneration. Experience in hiPSC work and RNA methods is an advantage. To apply, please send your motivation letter and CV with contact details of at least two referees to marina.chekulaeva(at)mdc-berlin.de
(1) von Kuegelgen and Chekulaeva (2020). WIREs RNA 14:e1590; (2) Ciolli Mattioli et al. (2018) Nucleic Acids Research, gky1270; (3) Zappulo et al. (2017) Nature Comm, s41467-017-00690-6